In reality, small chemical compounds of 700-1500 Da are not appropriate immunogens. But, when attached to macromolecules, they usually become great immunogenic agents. These small molecules are referred to as a hapten and macromolecules conferring hapten immunogenic are referred to as a carrier. The hapten can be thought of as an exogenous epitope linked to the carrier.

Tetracyclines (TCs) are broad-spectrum antibiotics discovered in the 1940s. They exhibit activity against a broad range of microorganisms (e.g. Gram-negative and Gram-positive bacteria, mycoplasmas, chlamydiae, and rickettsiae) and have extensively used to treat infectious diseases in both humans and animals. Specialized in the development of anti-hapten antibodies, Creative Biolabs offers a series of custom services for TC hapten design and synthesis, and helps clients to develop high-affinity small molecule antibodies against different targets.

Learn more: TCs hapten design